300.1K XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2025 | 431,000 | 2,256,372 | - | 0 | Common Stock | |
| Richard A. Waldron | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2025 | 100,000 | 333,263 | - | 0 | Common Stock | |
| Eric Sievers | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2025 | 175,000 | 370,032 | - | 0 | Common Stock | |
| Christian Vasquez | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2025 | 85,000 | 276,696 | - | 0 | Common Stock | |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.46 per share. | 16 Feb 2025 | 30,911 | 1,825,372 | - | 0.5 | 14,219 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.46 per share. | 15 Feb 2025 | 10,887 | 233,263 | - | 0.5 | 5,008 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.46 per share. | 15 Feb 2025 | 12,530 | 195,032 | - | 0.5 | 5,764 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.46 per share. | 15 Feb 2025 | 7,189 | 191,696 | - | 0.5 | 3,307 | Common Stock |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.77 per share. | 31 Aug 2024 | 2,181 | 298,050 | - | 1.8 | 3,860 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.77 per share. | 31 Aug 2024 | 572 | 207,562 | - | 1.8 | 1,012 | Common Stock |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.81 per share. | 31 Jul 2024 | 2,181 | 300,231 | - | 1.8 | 3,948 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.81 per share. | 31 Jul 2024 | 572 | 208,134 | - | 1.8 | 1,035 | Common Stock |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.37 per share. | 30 Jun 2024 | 2,181 | 302,412 | - | 1.4 | 2,988 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.37 per share. | 30 Jun 2024 | 572 | 208,706 | - | 1.4 | 784 | Common Stock |
| Lawrence J. Steinman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 16,500 | 54,959 | - | 0 | Common Stock | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 16,500 | 53,897 | - | 0 | Common Stock | |
| Sylvia McBrinn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 16,500 | 35,625 | - | 0 | Common Stock | |
| Scott A. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 16,500 | 304,593 | - | 0 | Common Stock | |
| Edward Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 16,500 | 36,700 | - | 0 | Common Stock | |
| Susan Moran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 16,500 | 28,807 | - | 0 | Common Stock | |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.51 per share. | 31 May 2024 | 2,181 | 288,093 | - | 1.5 | 3,293 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.51 per share. | 31 May 2024 | 572 | 209,278 | - | 1.5 | 864 | Common Stock |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.26 per share. | 30 Apr 2024 | 2,181 | 290,274 | - | 2.3 | 4,929 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.26 per share. | 30 Apr 2024 | 572 | 209,850 | - | 2.3 | 1,293 | Common Stock |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.44 per share. | 31 Mar 2024 | 2,181 | 292,455 | - | 3.4 | 7,503 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.44 per share. | 31 Mar 2024 | 572 | 210,422 | - | 3.4 | 1,968 | Common Stock |
| A. Scott Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.70 per share. | 29 Feb 2024 | 2,181 | 294,636 | - | 2.7 | 5,889 | Common Stock |
| Sievers Eric | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.70 per share. | 29 Feb 2024 | 572 | 210,994 | - | 2.7 | 1,544 | Common Stock |
| Jay Short M. | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2024 | 417,000 | 1,856,283 | - | 0 | Common Stock | |
| Sievers Eric | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2024 | 122,000 | 211,566 | - | 0 | Common Stock | |
| Richard A. Waldron | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2024 | 106,000 | 230,923 | - | 0 | Common Stock | |
| Vasquez Christian | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2024 | 70,000 | 185,659 | - | 0 | Common Stock | |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.92 per share. | 31 Jan 2024 | 2,181 | 296,817 | - | 1.9 | 4,188 | Common Stock |
| Sievers Eric | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.92 per share. | 31 Jan 2024 | 657 | 89,566 | - | 1.9 | 1,261 | Common Stock |
| Ann Gray Mary | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2023 | 5,995 | 37,397 | - | 0 | Common Stock | |
| Edward Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2023 | 4,827 | 20,200 | - | 0 | Common Stock | |
| A. Scott Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.46 per share. | 31 Dec 2023 | 1,791 | 298,998 | - | 2.5 | 4,406 | Common Stock |
| Sievers Eric | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.46 per share. | 31 Dec 2023 | 555 | 90,223 | - | 2.5 | 1,365 | Common Stock |
| Sylvia McBrinn | Director | Purchase of securities on an exchange or from another person at price $ 2.33 per share. | 26 Dec 2023 | 4,000 | 15,125 | - | 2.3 | 9,320 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 2.14 per share. | 20 Dec 2023 | 50,000 | 1,439,283 | - | 2.1 | 106,910 | Common Stock |
| Vasquez Christian | See Remarks | Purchase of securities on an exchange or from another person at price $ 2.04 per share. | 19 Dec 2023 | 7,495 | 115,659 | - | 2.0 | 15,262 | Common Stock |
| J. Lawrence Steinman | Director | Purchase of securities on an exchange or from another person at price $ 2.05 per share. | 19 Dec 2023 | 20,000 | 38,459 | - | 2.1 | 41,048 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.99 per share. | 31 Jul 2023 | 2,888 | 1,397,947 | - | 3.0 | 8,635 | Common Stock |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.99 per share. | 31 Jul 2023 | 1,791 | 307,953 | - | 3.0 | 5,355 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.99 per share. | 31 Jul 2023 | 970 | 127,833 | - | 3.0 | 2,900 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.99 per share. | 31 Jul 2023 | 554 | 92,996 | - | 3.0 | 1,656 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.99 per share. | 31 Jul 2023 | 194 | 101,744 | - | 3.0 | 580 | Common Stock |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 4,916 | 22,726 | - | 0 | Common Stock | |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.00 per share. | 30 Jun 2023 | 2,888 | 1,400,835 | - | 3 | 8,664 | Common Stock |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.00 per share. | 30 Jun 2023 | 1,791 | 309,744 | - | 3 | 5,373 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.00 per share. | 30 Jun 2023 | 970 | 125,780 | - | 3 | 2,910 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.00 per share. | 30 Jun 2023 | 555 | 90,527 | - | 3 | 1,665 | Common Stock |
| Edward Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 3,958 | 8,388 | - | 0 | Common Stock | |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.00 per share. | 30 Jun 2023 | 194 | 101,938 | - | 3 | 582 | Common Stock |
| Lawrence J. Steinman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Sylvia McBrinn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Scott A. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Scott A. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 5,895 | 5,895 | - | - | Stock Option (Right to Buy) | |
| Edward Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Susan Moran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2023 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.15 per share. | 31 May 2023 | 2,888 | 1,403,723 | - | 3.1 | 9,097 | Common Stock |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.15 per share. | 31 May 2023 | 1,791 | 311,535 | - | 3.2 | 5,642 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.15 per share. | 31 May 2023 | 970 | 126,750 | - | 3.2 | 3,056 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.15 per share. | 31 May 2023 | 554 | 91,082 | - | 3.1 | 1,745 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.15 per share. | 31 May 2023 | 194 | 102,132 | - | 3.1 | 611 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.37 per share. | 30 Apr 2023 | 2,888 | 1,406,611 | - | 3.4 | 9,733 | Common Stock |
| Scott A. Smith | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.37 per share. | 30 Apr 2023 | 1,791 | 313,326 | - | 3.4 | 6,036 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.37 per share. | 30 Apr 2023 | 970 | 127,720 | - | 3.4 | 3,269 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.37 per share. | 30 Apr 2023 | 555 | 91,636 | - | 3.4 | 1,870 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.37 per share. | 30 Apr 2023 | 194 | 102,326 | - | 3.4 | 654 | Common Stock |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 5,503 | 17,810 | - | 0 | Common Stock | |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.68 per share. | 31 Mar 2023 | 2,888 | 1,409,499 | - | 2.7 | 7,740 | Common Stock |
| Scott A. Smith | Director, Former President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.68 per share. | 31 Mar 2023 | 1,791 | 315,117 | - | 2.7 | 4,800 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.68 per share. | 31 Mar 2023 | 970 | 128,690 | - | 2.7 | 2,600 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.68 per share. | 31 Mar 2023 | 555 | 92,191 | - | 2.7 | 1,487 | Common Stock |
| Edward Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 4,430 | 4,430 | - | 0 | Common Stock | |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.68 per share. | 31 Mar 2023 | 189 | 102,520 | - | 2.7 | 507 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 2.47 per share. | 29 Mar 2023 | 40,800 | 1,412,387 | - | 2.5 | 100,862 | Common Stock |
| Christian Vasquez | See Remarks | Purchase of securities on an exchange or from another person at price $ 2.40 per share. | 28 Mar 2023 | 20,000 | 102,709 | - | 2.4 | 47,970 | Common Stock |
| Sylvia McBrinn | Director | Purchase of securities on an exchange or from another person at price $ 2.35 per share. | 28 Mar 2023 | 4,000 | 19,125 | - | 2.4 | 9,400 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2023 | 850,000 | 850,000 | - | - | Employee Stock Option (right to buy) | |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.89 per share. | 10 Feb 2023 | 2,888 | 1,371,587 | - | 2.9 | 8,346 | Common Stock |
| Scott A. Smith | Director, Former President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2023 | 350,000 | 350,000 | - | - | Employee Stock Option (right to buy) | |
| Scott A. Smith | Director, Former President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.98 per share. | 10 Feb 2023 | 1,791 | 316,908 | - | 3.0 | 5,337 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.98 per share. | 09 Feb 2023 | 970 | 129,660 | - | 3.0 | 2,891 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2023 | 210,000 | 210,000 | - | - | Employee Stock Option (right to buy) | |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.98 per share. | 09 Feb 2023 | 554 | 92,746 | - | 3.0 | 1,651 | Common Stock |
| Eric Sievers | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2023 | 240,000 | 240,000 | - | - | Employee Stock Option (right to buy) | |
| Christian Vasquez | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Feb 2023 | 135,000 | 135,000 | - | - | Employee Stock Option (right to buy) | |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.98 per share. | 09 Feb 2023 | 229 | 82,709 | - | 3.0 | 682 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.79 per share. | 31 Jan 2023 | 3,517 | 1,374,475 | - | 3.8 | 13,329 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.79 per share. | 31 Jan 2023 | 2,181 | 318,699 | - | 3.8 | 8,266 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.79 per share. | 31 Jan 2023 | 1,144 | 130,630 | - | 3.8 | 4,336 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.79 per share. | 31 Jan 2023 | 654 | 93,300 | - | 3.8 | 2,479 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.79 per share. | 31 Jan 2023 | 229 | 82,938 | - | 3.8 | 868 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.25 per share. | 31 Dec 2022 | 4,667 | 1,377,992 | - | 8.3 | 38,503 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.25 per share. | 31 Dec 2022 | 1,791 | 320,880 | - | 8.3 | 14,776 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.25 per share. | 31 Dec 2022 | 970 | 131,774 | - | 8.3 | 8,003 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.25 per share. | 31 Dec 2022 | 554 | 93,954 | - | 8.3 | 4,571 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.25 per share. | 31 Dec 2022 | 194 | 83,167 | - | 8.3 | 1,601 | Common Stock |
| Sylvia McBrinn | Director | Purchase of securities on an exchange or from another person at price $ 8.33 per share. | 19 Dec 2022 | 3,700 | 9,125 | - | 8.3 | 30,813 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.01 per share. | 30 Nov 2022 | 4,667 | 1,382,659 | - | 11.0 | 51,384 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.01 per share. | 30 Nov 2022 | 1,791 | 322,671 | - | 11.0 | 19,719 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.01 per share. | 30 Nov 2022 | 970 | 132,744 | - | 11.0 | 10,680 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.01 per share. | 30 Nov 2022 | 555 | 94,508 | - | 11.0 | 6,111 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.01 per share. | 30 Nov 2022 | 194 | 83,361 | - | 11.0 | 2,136 | Common Stock |
| Sylvia McBrinn | Director | Purchase of securities on an exchange or from another person at price $ 8.27 per share. | 22 Nov 2022 | 2,000 | 5,425 | - | 8.3 | 16,540 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.89 per share. | 31 Oct 2022 | 3,454 | 1,387,326 | - | 6.9 | 23,798 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.89 per share. | 31 Oct 2022 | 1,791 | 324,462 | - | 6.9 | 12,340 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.89 per share. | 31 Oct 2022 | 970 | 123,714 | - | 6.9 | 6,683 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.89 per share. | 31 Oct 2022 | 554 | 85,063 | - | 6.9 | 3,817 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.89 per share. | 31 Oct 2022 | 194 | 73,555 | - | 6.9 | 1,337 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.70 per share. | 30 Sep 2022 | 2,888 | 1,390,780 | - | 7.7 | 22,238 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.70 per share. | 30 Sep 2022 | 1,791 | 326,253 | - | 7.7 | 13,791 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.70 per share. | 30 Sep 2022 | 970 | 124,684 | - | 7.7 | 7,469 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.70 per share. | 30 Sep 2022 | 555 | 85,617 | - | 7.7 | 4,274 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.70 per share. | 30 Sep 2022 | 194 | 73,749 | - | 7.7 | 1,494 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.71 per share. | 31 Aug 2022 | 2,888 | 1,393,668 | - | 8.7 | 25,154 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.71 per share. | 31 Aug 2022 | 1,791 | 328,044 | - | 8.7 | 15,600 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.71 per share. | 31 Aug 2022 | 970 | 125,654 | - | 8.7 | 8,449 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.71 per share. | 31 Aug 2022 | 555 | 86,172 | - | 8.7 | 4,834 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.71 per share. | 31 Aug 2022 | 194 | 73,943 | - | 8.7 | 1,690 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 7.84 per share. | 12 Aug 2022 | 26,350 | 1,396,556 | - | 7.8 | 206,600 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.40 per share. | 31 Jul 2022 | 2,888 | 1,370,206 | - | 3.4 | 9,819 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.40 per share. | 31 Jul 2022 | 1,791 | 329,835 | - | 3.4 | 6,089 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.40 per share. | 31 Jul 2022 | 970 | 126,624 | - | 3.4 | 3,298 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.40 per share. | 31 Jul 2022 | 554 | 86,727 | - | 3.4 | 1,884 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.40 per share. | 31 Jul 2022 | 194 | 74,137 | - | 3.4 | 660 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.85 per share. | 30 Jun 2022 | 2,888 | 1,373,094 | - | 2.9 | 8,231 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.85 per share. | 30 Jun 2022 | 1,791 | 331,626 | - | 2.8 | 5,104 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.85 per share. | 30 Jun 2022 | 970 | 127,594 | - | 2.9 | 2,765 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.85 per share. | 30 Jun 2022 | 555 | 87,281 | - | 2.9 | 1,582 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.85 per share. | 30 Jun 2022 | 194 | 74,331 | - | 2.9 | 553 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 2.91 per share. | 21 Jun 2022 | 40,308 | 1,375,982 | - | 2.9 | 117,296 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 2.79 per share. | 21 Jun 2022 | 29,082 | 1,335,674 | - | 2.8 | 81,040 | Common Stock |
| Christian Vasquez | See Remarks | Purchase of securities on an exchange or from another person at price $ 3.04 per share. | 07 Jun 2022 | 14,152 | 38,677 | - | 3.0 | 43,007 | Common Stock |
| Christian Vasquez | See Remarks | Purchase of securities on an exchange or from another person at price $ 2.97 per share. | 07 Jun 2022 | 10,000 | 74,525 | - | 3.0 | 29,720 | Common Stock |
| Christian Vasquez | See Remarks | Purchase of securities on an exchange or from another person at price $ 3.02 per share. | 07 Jun 2022 | 25,848 | 64,525 | - | 3.0 | 78,188 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.41 per share. | 31 May 2022 | 1,791 | 333,417 | - | 2.4 | 4,316 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.41 per share. | 31 May 2022 | 970 | 128,564 | - | 2.4 | 2,338 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.41 per share. | 31 May 2022 | 554 | 87,836 | - | 2.4 | 1,335 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.41 per share. | 31 May 2022 | 194 | 24,525 | - | 2.4 | 468 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.48 per share. | 30 Apr 2022 | 2,888 | 1,304,102 | - | 3.5 | 10,050 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.48 per share. | 30 Apr 2022 | 1,791 | 335,208 | - | 3.5 | 6,233 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.48 per share. | 30 Apr 2022 | 970 | 129,534 | - | 3.5 | 3,376 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.48 per share. | 30 Apr 2022 | 555 | 88,390 | - | 3.5 | 1,931 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.48 per share. | 30 Apr 2022 | 189 | 24,719 | - | 3.5 | 658 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.00 per share. | 31 Mar 2022 | 2,888 | 1,306,990 | - | 5 | 14,440 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.00 per share. | 31 Mar 2022 | 1,791 | 336,999 | - | 5 | 8,955 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.00 per share. | 31 Mar 2022 | 970 | 130,504 | - | 5 | 4,850 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.00 per share. | 31 Mar 2022 | 554 | 88,945 | - | 5 | 2,770 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.00 per share. | 31 Mar 2022 | 189 | 24,908 | - | 5 | 945 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.48 per share. | 28 Feb 2022 | 2,888 | 1,309,878 | - | 6.5 | 18,714 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.48 per share. | 28 Feb 2022 | 1,791 | 338,790 | - | 6.5 | 11,606 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.48 per share. | 28 Feb 2022 | 970 | 131,474 | - | 6.5 | 6,286 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.48 per share. | 28 Feb 2022 | 555 | 89,499 | - | 6.5 | 3,596 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.48 per share. | 28 Feb 2022 | 230 | 25,097 | - | 6.5 | 1,490 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 337,000 | 337,000 | - | - | Employee Stock Option (right to buy) | |
| Scott A. Smith | Director, President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2022 | 200,000 | 200,000 | - | - | Employee Stock Option (right to buy) | |
| Richard A. Waldron | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2022 | 115,000 | 115,000 | - | - | Employee Stock Option (right to buy) | |
| Eric Sievers | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2022 | 122,000 | 122,000 | - | - | Employee Stock Option (right to buy) | |
| Christian Vasquez | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2022 | 44,000 | 44,000 | - | - | Employee Stock Option (right to buy) | |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.56 per share. | 31 Jan 2022 | 3,378 | 1,312,766 | - | 9.6 | 32,294 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.56 per share. | 31 Jan 2022 | 2,181 | 340,581 | - | 9.6 | 20,850 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.56 per share. | 31 Jan 2022 | 1,150 | 132,444 | - | 9.6 | 10,994 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.56 per share. | 31 Jan 2022 | 657 | 90,054 | - | 9.6 | 6,281 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.56 per share. | 31 Jan 2022 | 230 | 25,327 | - | 9.6 | 2,199 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.63 per share. | 31 Dec 2021 | 4,667 | 1,316,144 | - | 19.6 | 91,613 | Common Stock |
| Scott A. Smith | Director, President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.63 per share. | 31 Dec 2021 | 2,894 | 342,762 | - | 19.6 | 56,809 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.63 per share. | 31 Dec 2021 | 1,391 | 133,078 | - | 19.6 | 27,305 | Common Stock |
| Eric Sievers | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.63 per share. | 31 Dec 2021 | 795 | 90,711 | - | 19.6 | 15,606 | Common Stock |
| Christian Vasquez | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.63 per share. | 31 Dec 2021 | 194 | 25,065 | - | 19.6 | 3,808 | Common Stock |
| Edward Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 23.89 per share. | 29 Nov 2021 | 15,435 | 1,368,433 | - | 23.9 | 368,742 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 23.89 per share. | 29 Nov 2021 | 399 | 349,746 | - | 23.9 | 9,532 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 23.89 per share. | 29 Nov 2021 | 4,599 | 148,659 | - | 23.9 | 109,870 | Common Stock |
| Eric Sievers | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 23.89 per share. | 29 Nov 2021 | 110 | 92,630 | - | 23.9 | 2,628 | Common Stock |
| Christian Vasquez | See Remarks | Sale of securities on an exchange or to another person at price $ 23.89 per share. | 29 Nov 2021 | 642 | 27,238 | - | 23.9 | 15,337 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 24.28 per share. | 22 Nov 2021 | 15,861 | 1,409,972 | - | 24.3 | 385,184 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 25.77 per share. | 22 Nov 2021 | 4,859 | 1,383,868 | - | 25.8 | 125,221 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 22 Nov 2021 | 5,852 | 1,388,727 | - | 25.0 | 146,294 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 24.05 per share. | 22 Nov 2021 | 6,311 | 1,394,579 | - | 24.1 | 151,798 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 26.04 per share. | 22 Nov 2021 | 9,082 | 1,400,890 | - | 26.0 | 236,450 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 26.24 per share. | 22 Nov 2021 | 15,675 | 1,425,833 | - | 26.2 | 411,234 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 25.77 per share. | 22 Nov 2021 | 133 | 350,145 | - | 25.8 | 3,428 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 26.23 per share. | 22 Nov 2021 | 430 | 351,295 | - | 26.2 | 11,281 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 24.29 per share. | 22 Nov 2021 | 435 | 350,860 | - | 24.3 | 10,564 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 26.04 per share. | 22 Nov 2021 | 249 | 350,611 | - | 26.0 | 6,483 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 24.05 per share. | 22 Nov 2021 | 173 | 350,438 | - | 24.1 | 4,161 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 22 Nov 2021 | 160 | 350,278 | - | 25 | 4,000 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.05 per share. | 22 Nov 2021 | 1,459 | 155,736 | - | 24.1 | 35,093 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 22 Nov 2021 | 1,354 | 154,382 | - | 25.0 | 33,849 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.77 per share. | 22 Nov 2021 | 1,124 | 153,258 | - | 25.8 | 28,967 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.04 per share. | 22 Nov 2021 | 2,101 | 157,195 | - | 26.0 | 54,700 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.29 per share. | 22 Nov 2021 | 3,669 | 159,296 | - | 24.3 | 89,102 | Common Stock |
| Richard A. Waldron | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.23 per share. | 22 Nov 2021 | 3,626 | 162,965 | - | 26.2 | 95,128 | Common Stock |
| Eric Sievers | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.29 per share. | 22 Nov 2021 | 119 | 92,937 | - | 24.3 | 2,890 | Common Stock |
| Eric Sievers | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.78 per share. | 22 Nov 2021 | 37 | 92,740 | - | 25.8 | 954 | Common Stock |
| Eric Sievers | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 22 Nov 2021 | 44 | 92,777 | - | 25 | 1,100 | Common Stock |
| Eric Sievers | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.06 per share. | 22 Nov 2021 | 48 | 92,821 | - | 24.1 | 1,155 | Common Stock |
| Eric Sievers | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 26.03 per share. | 22 Nov 2021 | 68 | 92,869 | - | 26.0 | 1,770 | Common Stock |
| Eric Sievers | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 26.24 per share. | 22 Nov 2021 | 118 | 93,056 | - | 26.2 | 3,096 | Common Stock |
| Christian Vasquez | See Remarks | Sale of securities on an exchange or to another person at price $ 24.05 per share. | 22 Nov 2021 | 278 | 28,352 | - | 24.1 | 6,687 | Common Stock |
| Christian Vasquez | See Remarks | Sale of securities on an exchange or to another person at price $ 26.23 per share. | 22 Nov 2021 | 691 | 29,730 | - | 26.2 | 18,128 | Common Stock |
| Christian Vasquez | See Remarks | Sale of securities on an exchange or to another person at price $ 24.28 per share. | 22 Nov 2021 | 699 | 29,031 | - | 24.3 | 16,975 | Common Stock |
| Christian Vasquez | See Remarks | Sale of securities on an exchange or to another person at price $ 26.03 per share. | 22 Nov 2021 | 401 | 28,630 | - | 26.0 | 10,440 | Common Stock |
| Christian Vasquez | See Remarks | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 22 Nov 2021 | 258 | 28,094 | - | 25 | 6,450 | Common Stock |
| Christian Vasquez | See Remarks | Sale of securities on an exchange or to another person at price $ 25.77 per share. | 22 Nov 2021 | 214 | 27,880 | - | 25.8 | 5,515 | Common Stock |
| Lawrence J. Steinman | Director | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 02 Nov 2021 | 450 | 18,459 | - | 30 | 13,500 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 30.18 per share. | 01 Oct 2021 | 2,994 | 351,725 | - | 30.2 | 90,351 | Common Stock |
| Eric Sievers | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.39 per share. | 01 Oct 2021 | 592 | 93,174 | - | 30.4 | 17,993 | Common Stock |
| Guy Levy | Director | Grant, award, or other acquisition of securities at price $ 28.00 per share. | 30 Sep 2021 | 267,900 | 1,115,817 | - | 28 | 7,501,200 | Common Stock |
| Lawrence J. Steinman | Director | Sale of securities on an exchange or to another person at price $ 36.82 per share. | 15 Sep 2021 | 450 | 18,909 | - | 36.8 | 16,569 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 40.89 per share. | 26 Aug 2021 | 13,849 | 354,719 | - | 40.9 | 566,227 | Common Stock |
| Scott A. Smith | Director, President | Sale of securities on an exchange or to another person at price $ 39.63 per share. | 26 Aug 2021 | 19,395 | 368,568 | - | 39.6 | 768,699 | Common Stock |
| Eric Sievers | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 39.59 per share. | 26 Aug 2021 | 6,883 | 93,766 | - | 39.6 | 272,496 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 41.60 per share. | 24 Aug 2021 | 4,533 | 793,547 | - | 41.6 | 188,573 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2021 | 7,747 | 0 | - | - | Employee Stock Option (right to buy) | |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.00 per share. | 24 Aug 2021 | 7,747 | 798,080 | - | 18 | 139,446 | Common Stock |
| Guy Levy | Director | Sale of securities on an exchange or to another person at price $ 39.65 per share. | 24 Aug 2021 | 285,874 | 1,167,378 | - | 39.6 | 11,334,904 | Common Stock |
| Guy Levy | Director | Sale of securities on an exchange or to another person at price $ 39.65 per share. | 24 Aug 2021 | 53,195 | 217,358 | - | 39.7 | 2,109,182 | Common Stock |
| Guy Levy | Director | Sale of securities on an exchange or to another person at price $ 39.65 per share. | 24 Aug 2021 | 207,640 | 847,917 | - | 39.7 | 8,232,926 | Common Stock |
| Lawrence J. Steinman | Director | Sale of securities on an exchange or to another person at price $ 40.60 per share. | 16 Aug 2021 | 450 | 19,359 | - | 40.6 | 18,270 | Common Stock |
| Lawrence J. Steinman | Director | Sale of securities on an exchange or to another person at price $ 38.29 per share. | 15 Jul 2021 | 450 | 19,809 | - | 38.3 | 17,231 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 07 Jul 2021 | 5,378 | 1,309,480 | - | 0 | Common Stock | |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.41 per share. | 07 Jul 2021 | 2,888 | 1,306,592 | - | 2.4 | 6,960 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 38.24 per share. | 17 Jun 2021 | 17,575 | 827,758 | - | 38.2 | 672,147 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 39.22 per share. | 17 Jun 2021 | 19,269 | 845,333 | - | 39.2 | 755,753 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 39.89 per share. | 17 Jun 2021 | 1,700 | 790,333 | - | 39.9 | 67,820 | Common Stock |
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 39.54 per share. | 17 Jun 2021 | 35,725 | 792,033 | - | 39.5 | 1,412,406 | Common Stock |
| Guy Levy | Director | Sale of securities on an exchange or to another person at price $ 39.16 per share. | 17 Jun 2021 | 337,220 | 1,453,252 | - | 39.2 | 13,205,535 | Common Stock |
| Guy Levy | Director | Sale of securities on an exchange or to another person at price $ 39.16 per share. | 17 Jun 2021 | 62,780 | 270,553 | - | 39.2 | 2,458,465 | Common Stock |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 12,307 | 12,307 | - | - | Stock Option (right to buy) | |
| Sylvia McBrinn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 24,615 | 24,615 | - | - | Stock Option (right to buy) | |
| Guy Levy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 12,307 | 12,307 | - | - | Stock Option (right to buy) | |
| Susan Moran | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2021 | 12,307 | 12,307 | - | - | Stock Option (right to buy) | |
| Lawrence J. Steinman | Director | Other type of transaction at price $ 0.00 per share. | 14 Jun 2021 | 5,388 | 20,259 | - | 0 | Common Stock | |
| Lawrence J. Steinman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2021 | 12,307 | 12,307 | - | - | Stock Option (right to buy) | |
| Scott A. Smith | Director, President | Other type of transaction at price $ 0.00 per share. | 14 Jun 2021 | 34,963 | 387,963 | - | 0 | Common Stock | |
| Richard A. Waldron | Chief Financial Officer | Other type of transaction at price $ 0.00 per share. | 14 Jun 2021 | 31,976 | 166,591 | - | 0 | Common Stock | |
| Eric Sievers | Chief Medical Officer | Other type of transaction at price $ 0.00 per share. | 14 Jun 2021 | 23,726 | 100,649 | - | 0 | Common Stock | |
| Christian Vasquez | See Remarks | Other type of transaction at price $ 0.00 per share. | 14 Jun 2021 | 3,498 | 30,421 | - | 0 | Common Stock | |
| Guy Levy | Director | Purchase of securities on an exchange or from another person at price $ 18.00 per share. | 18 Dec 2020 | 1,055,557 | 1,055,557 | - | 18 | 19,000,026 | Common Stock |
| Guy Levy | Director | 18 Dec 2020 | 1,790,472 | 1,790,472 | - | 0 | Common Stock | ||
| Guy Levy | Director | Purchase of securities on an exchange or from another person at price $ 18.00 per share. | 18 Dec 2020 | 333,333 | 333,333 | - | 18 | 5,999,994 | Common Stock |
| Guy Levy | Director | 18 Dec 2020 | 1,790,472 | 0 | - | - | Series D Convertible Preferred Stock | ||
| Jay M. Short | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2020 | 30,988 | 30,988 | - | - | Employee Stock Option (right to buy) | |
| Scott A. Smith | Director, President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2020 | 154,943 | 154,943 | - | - | Employee Stock Option (right to buy) | |
| Richard A. Waldron | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2020 | 30,988 | 30,988 | - | - | Employee Stock Option (right to buy) | |
| Eric Sievers | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2020 | 77,471 | 77,471 | - | - | Employee Stock Option (right to buy) | |
| Carolyn Anderson Short | See Remarks, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2020 | 7,747 | 7,747 | - | - | Employee Stock Option (right to buy) | |
| Christian Vasquez | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2020 | 9,296 | 9,296 | - | - | Employee Stock Option (right to buy) |